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Bioceramics and bioactive glasses for Life Sciences

Lupe

Ceramics and glasses are widely used materials in medicine, mostly for implants. Classical ceramics, like alumina (Al2O3) and zirconia (ZrO2) are valued because of their high mechanical properties and bioinert qualities. Other ceramics and glasses have showed bioactive properties, supporting or enhancing regeneration of damaged tissues, like bone. Bioactive ceramics, like hydroxyapatites (HAp) and bioactive glasses, are therefore very interesting and promising materials for bone substitution and repair. Especially mechanical properties, chemical composition and surface science are areas of further improvement, to produce the ideal biomaterial. We develop macroporous ceramic foams as bone substitutes, tissue engineering substrates or bioreactors, consisting of Al2O3 and HAp. Furthermore we produce bioactive glasses with varying compositions through different techniques, some of them mesoporous, which is interesting in many aspects of life sciences, e.g. drug release. Additionally we develop biodegradable composite materials to improve mechanical and chemical properties of ceramics and glasses, and surface coatings to improve bioactivity and cell and tissue adhesion of bioinert materials.

Topics

  • macroporous ceramic foams for tissue engineering and bone regeneration
  • melt derived bioglass with varying chemical composititions
  • sol-gel derived mesoporous bioglass for drug release
  • bioglass-polylactide composite powders for additive manufacturing of implants
  • metal-polymer composites with electrical and chemical stimulation as biomaterials
  • PLGA or protein consisting scaffolds for tissue engineering
  • functional coatings on silicone, titanium and oxide ceramics to enhance wettability, cell adhesion
Representative publications
1. A method to screen and evaluate tissue adhesives for joint repair applications. In: BMC Musculoskeletal Disorders 13 (2012), Nr. 1, 175. – ISSN 1471–2474
Dehne, T.; Zehbe, R.; Kruger, J.; Petrova, A.; Valbuena, R.; Sittinger, M.; Schubert, H.; Ringe, J.
2. From 2D slices to 3D volumes: Image based reconstruction and morphological characterization of hippocampal cells on charged and uncharged surfacesusing FIB/SEM serial sectioning. In: Ultramicroscopy 111 (2011), Nr. 4, 259. - 266. ISSN 0304–3991
Schmidt, F.; Kühbacher, M.; Gross, U.; Kyriakopoulos, A.; Schubert, H.;Zehbe, R.
3. High Resolution X-Ray Tomography - 3D Imaging for Tissue Engineering Applications. In: Tissue Engineering. InTech (2010), S. 337 –357
Book chapter: Zehbe, R.; Haibel, A.; Schmidt, F.; Riesemeyer, H.; Kirkpatrick, C. J.; Schubert, H.; Brochhausen, C.

 Contact: Dr.-Ing. Franziska Schmidt (franziska.schmidt(at)ceramics.tu-berlin.de)

 


 

 

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Dr. Franziska Schmidt
Franziska.Schmidt(at)cermics.tu-berlin.de
+49(0) 30 314 24093